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Immunological Synapse

Antigen presentation in the form of an immunological synapse between dendritic cell and t cell, love is in the air

Antigen presentation in the form of an immunological synapse between dendritic cell and t cell, love is in the air

In an immunological synapse the membrane between the antigen presenting cell (APC) and the t cell touch. They exchange signals so the APC can present an antigen to the t cell. In this case the APC is a dendritic cell that has the right antigen for the t cell and love is in the air. …

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Fears of an Adipocyte

cartoon of a fat cell or adipocyte

cartoon of a fat cell or adipocyte

Adipocytes are fat cells, which specialize in storing energy as fat. There are lots of people out there who make their new year’s resolutions to loose weight. It is no surprising that these fat cells are scared of shrinking or disappearing completely.

Red Blood Cell Lysis

red blood cell lysis illustration, red cell lysing after adding buffer

red blood cell lysis illustration, red cell lysing after adding buffer

To analyze cells in the blood sometimes the red blood cells (RBCs) need to be removed. This can be done by lysing the cells. There are various RBC lysis buffers available that do just that. Protocols: Red Blood Cell Lysis  Protocol by Centre of Immunology and Transplantation Red Blood Cell Lysis Using ACK Lysing Buffer …

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Shooting Antibodies

Plasma cell; B cell; shooting antibodies with a sling

Plasma cell; B cell; shooting antibodies with a sling

Plasma cells, are a specialized type of B cells that produce large volumes of antibodies. This B cell here is using those antibodies to neutralize an invading flu virus that has entered the body.

Adoptive Cell Transfer

Adoptive cell transfer of CD45.2 T lymphocytes to new host CD45.1 mouse host

Adoptive cell transfer of CD45.2 T lymphocytes to new host CD45.1 mouse host

Adoptive cell transfer refers to the transfer of cells into an organism, which could be a patient or in the case of this cartoon, a mouse. This is a very common technique used in immunology research to understand how the cells behave. Adoptive Cell Transfer in Immunology Research Typically, the cells that are being transfer …

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Host-Pathogen Battles

Cartoon Host-Pathogen Arm Wrestling

Cartoon Host-Pathogen Arm Wrestling

This cartoon is showing the battle between a leukocyte and a bacterium. Who will win? The interactions between the host cell and a pathogen trying to invade an organism, commonly referred to as host-pathogen interactions, are very important to understand disease. Each pathogen might have a unique way of interacting with their host and the …

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Monocyte-Derived Dendritic Cell

cartoon of monocyte-dericed dendritic cell

cartoon of monocyte-dericed dendritic cell

This monocyte turned into a dendritic cell (DC) and doesn’t even know how it happened! Many researchers isolate monocytes and then derive them into DCs to do studies on these cells. It is a common method followed by people studying DCs that need to generate some cells for their experiments. In case you are interested in …

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MHC Restriction

Cartoon of Dendritic Cell Presenting Antigen on MHC to T Cell

Cartoon of Dendritic Cell Presenting Antigen on MHC to T Cell

The dendritic cell (DC) is presenting an antigen to a T cell but the T cell doesn’t recognize it. This is making the DC kind of sad. In this case the DC is presenting the antigen on an MHC-I molecule and it is showing to a CD8 T cells. However, the T cell will recognize and …

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