To analyze cells in the blood sometimes the red blood cells (RBCs) need to be removed. This can be done by lysing the cells. There are various RBC lysis buffers available that do just that.
Protocols:
Red Blood Cell Lysis Protocol by Centre of Immunology and Transplantation
Red Blood Cell Lysis Using ACK Lysing Buffer by ThemrmoFisher Scientific
Red blood cell lysis using Biolegend lysis buffer
Other useful links
Forum discussing how RBC lysis buffer works
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