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Character: Lymphocyte

Antigen presentation in the form of an immunological synapse between dendritic cell and t cell, love is in the air

Immunological Synapse

Antigen presentation in the form of an immunological synapse between dendritic cell and t cell, love is in the air

In an immunological synapse the membrane between the antigen presenting cell (APC) and the t cell touch. They exchange signals so the APC can present an antigen to the t cell. In this case the APC is a dendritic cell that has the right antigen for the t cell and love is in the air. …

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illustration of red blood cell and lymphocyte nucleus with DAPI stanining

DAPI

illustration of red blood cell and lymphocyte nucleus with DAPI stanining

DAPI stands for 4′,6-diamidino-2-phenylindole and it is a fluorescent stain that binds to DNA in the nucleus. It is a stain used very often in fluorescence microscopy, when excited with ultraviolet light DAPI emits a blue light. This makes the stain very popular in fluorescence microscopy making the nuclei visible in a blue colour. As …

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Adoptive cell transfer of CD45.2 T lymphocytes to new host CD45.1 mouse host

Adoptive Cell Transfer

Adoptive cell transfer of CD45.2 T lymphocytes to new host CD45.1 mouse host

Adoptive cell transfer refers to the transfer of cells into an organism, which could be a patient or in the case of this cartoon, a mouse. This is a very common technique used in immunology research to understand how the cells behave. Adoptive Cell Transfer in Immunology Research Typically, the cells that are being transfer …

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Cartoon of Dendritic Cell Presenting Antigen on MHC to T Cell

MHC Restriction

Cartoon of Dendritic Cell Presenting Antigen on MHC to T Cell

The dendritic cell (DC) is presenting an antigen to a T cell but the T cell doesn’t recognize it. This is making the DC kind of sad. In this case the DC is presenting the antigen on an MHC-I molecule and it is showing to a CD8 T cells. However, the T cell will recognize and …

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Cartoon of Dendritic Cell and Lymphocyte in the intestine

Dendritic Cell in the intestine

Cartoon of Dendritic Cell and Lymphocyte in the intestine

A big challenge of the immune system in the intestine is being able to distinguish between harmful pathogens and at the same time be tolerant towards harmless antigens derived from food and commensal bacteria (good bacteria). Mechanisms to maintain tolerance are therefore necessary to avoid unwanted immune responses that may lead to inflammatory bowel diseases (IBD) …

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