Leukocyte extravasation is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection. This process is regulated by a concerted action between endothelial cells and leukocytes, whereby endothelial cells activate leukocytes and direct them to extravasation sites, and leukocytes in turn instruct endothelial cells to open a path for transmigration.
To learn more about leukocyte extravasation and some of the mechanisms involved in this process check out these resources:
- Video by Garland Science
- Review published by NATURE REVIEWS IMMUNOLOGY
- Overview of extravasation shown in the book Immunobiology, 5th edition
Below is a figure from the Nature Immunolog review, that I mentioned above, with an illustration of the steps involved in leukocyte extravasation.
How leukocytes cross the vascular endothelium Nature Reviews Immunology